The borough was created following the 2002 municipal reorganization of Montreal. It comprises two main neighbourhoods, Côte-des-Neiges and Notre-Dame-de-Grâce, both former towns that were annexed by the city of Montreal in 1910.
Côte-des-Neiges–Notre-Dame-de-Grâce is the most populous borough of Montreal, with a population of 165,031 according to the 2011 Census. It is an ethnically diverse borough, with 75 different nationalities present. There is also a large student population due to the presence of two universities, Université de Montréal and the Loyola campus of Concordia University.